Figure 3.

CIC-Regulated Genes Are Not Increased by 3 i.c.v. ASO Injections into Atxn1^2Q/2Q Mice

(A–C) RNA-seq analysis of Atxn1 (open circle) and a set of CIC-regulated genes associated with increased risk of glioma (A) in the cerebral cortex, (B) in the cerebellum, and (C) in the medulla at 26 weeks of age following 3 i.c.v. injections of Atxn1-targeting ASO at 5, 13, and 21 weeks of age. Horizontal dashed lines indicate the position of p = 0.05. Four values are not depicted, as their p values were essentially 1: Spred1 and Etv4 (cortex), Etv4 (cerebellum), and Six1 (medulla). Non-targeting ASO (n = 4), Atxn1-targeting ASO353 (n = 4).