Table 3.
OnabotulinumtoxinA treatment utilization for the most common lower limb clinical presentations.a
| Stroke (N=411) | MS (N=119) | CP (N=77) | TBI (N=45) | SCI (N=42) | |
|---|---|---|---|---|---|
| EQUINOVARUS FOOT | |||||
| Patients, N (%) | 217 (52.8) | 72 (60.5) | 38 (49.4) | 28 (62.2) | 20 (47.6) |
| Treatment sessions, n | 577 | 209 | 100 | 65 | 51 |
| Dose (U) | |||||
| Mean (SD) | 223 (131) | 206 (124) | 162 (116) | 223 (109) | 277 (168) |
| Mode | 300 | 300 | 100 | 150 | 200 |
| Min, Max | 15, 630 | 20, 875 | 20, 480 | 50, 450 | 60, 900 |
| Localization method, n (%)b | |||||
| Anatomical | 175 (30.3) | 113 (54.1) | 22 (22.0) | 11 (16.9) | 22 (43.1) |
| E-stim | 180 (31.2) | 60 (28.7) | 22 (22.0) | 42 (64.6) | 13 (25.5) |
| EMG | 288 (49.9) | 113 (54.1) | 52 (52.0) | 21 (32.3) | 16 (31.4) |
| Ultrasound | 155 (26.9) | 37 (17.7) | 17 (17.0) | 10 (15.4) | 13 (25.5) |
| FLEXED KNEE | |||||
| Patients, N (%) | 39 (9.5) | 32 (26.9) | 26 (33.8) | 12 (26.7) | 9 (21.4) |
| Treatment sessions, n | 80 | 99 | 66 | 17 | 24 |
| Dose (U) | |||||
| Mean (SD) | 143 (86) | 181 (122) | 150 (89) | 154 (60) | 165 (84) |
| Mode | 100 | 150 | 100 | 150 | 200 |
| Min, Max | 15, 500 | 20, 550 | 30, 325 | 75, 300 | 50, 300 |
| Localization method, n (%)b | |||||
| Anatomical | 46 (57.5) | 67 (67.7) | 19 (28.8) | 1 ( 5.9) | 10 (41.7) |
| E-stim | 10 (12.5) | 2 ( 2.0) | 0 ( 0.0) | 5 (29.4) | 1 ( 4.2) |
| EMG | 49 (61.3) | 45 (45.5) | 49 (74.2) | 9 (52.9) | 15 (62.5) |
| Ultrasound | 4 ( 5.0) | 6 ( 6.1) | 5 ( 7.6) | 3 (17.6) | 4 (16.7) |
| ADDUCTED THIGH | |||||
| Patients, N (%) | 20 (4.9) | 38 (9.2) | 17 (22.1) | 7 (15.6) | 9 (21.4) |
| Treatment sessions, n | 43 | 107 | 43 | 15 | 22 |
| Dose (U) | |||||
| Mean (SD) | 112 (54) | 173 (112) | 163 (94) | 166 (114) | 140 (66) |
| Mode | 100 | 200 | 100 | 150 | 100 |
| Min, Max | 20, 240 | 25, 500 | 40, 550 | 35, 400 | 50, 300 |
| Localization method, n (%)b | |||||
| Anatomical | 17 (39.5) | 77 (72.0) | 19 (44.2) | 2 (13.3) | 13 (59.1) |
| E-stim | 11 (25.6) | 8 ( 7.5) | 1 ( 2.3) | 4 (26.7) | 4 (18.2) |
| EMG | 18 (41.9) | 38 (35.5) | 23 (53.5) | 9 (60.0) | 11 (50.0) |
| Ultrasound | 3 ( 7.0) | 8 ( 7.5) | 0 ( 0.0) | 2 (13.3) | 1 ( 4.5) |
CP: cerebral palsy, E-stim: electrical stimulation, EMG: electromyography, Max: maximum, mL: milliliter, Min: minimum, MS: multiple sclerosis, N: number of patients, n: number of treatment sessions, SCI: spinal cord injury, SD: standard deviation, TBI: traumatic brain injury, U: units of onabotulinumtoxinA.
For each etiology, the lower limb spasticity presentations were first ranked by number of patients treated: highest to lowest. Next, the number of times each spasticity presentation was included in the top 3 ranking was counted and the 3 presentations with the highest number of top 3 rankings are shown here. Lower limb spasticity presentations are not mutually exclusive, and therefore, may add up to greater than 100%.
Localization methods were not mutually exclusive and may have been influenced by availability of equipment at the site. “Anatomical” localization refers to palpation. Data represents the sum across all treatment sessions in the 1-year interim analysis.