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Proposed mechanism of NCOA4 regulation under hypoxia. In human macrophages nuclear receptor coactivator 4 (NCOA4) mRNA is reduced under hypoxia by decreased transcription and in parallel by micro RNA (miR)-6862-5p, which is regulated by c-Jun N-terminal kinase (JNK). As result, NCOA4 protein and consequently ferritinophagy are decreased. In turn, this increases FTMT abundance under hypoxia, which protects from ferroptosis.
