Table 1.

Sequences Used in This Work

	Passenger Strand	Guide Strand
US09	fC.mA.fG.mA.fA.mG.fC.mU.fG.mA.fU.mC.fA#mA#fA-Chol	PmU.fU.mU.fG.mA.fU.mC.fA.mG.fC.mU.fU.mC.fU#mG#fA#mC#fA#mG#fC
NTC	fU.mU.fA.mC.fA.mU.fG.mU.fU.mU.fU.mC.fC#mU#fA-Chol	PmU.fA.mG.fG.mA.fA.mA.fA.mC.fA.mU.fG.mU.fA#mA#fA#mC#fC#mA#fA

The modifications are as follows: m, 2′-OMe; f, 2′-fluoro; #, thiophosphate; Chol, cholesteryl-TEG.