Table 5.
The enriched most significant function for the differentially expressed genes involved in 11 modules of PPI network.
| Module | Description | Term | Gene number | P-value |
|---|---|---|---|---|
| 1 | mRNA processing | GO:0006397 | 217 | 1.71E-37 |
| 2 | chemokine receptor activity | GO:0004950 | 125 | 5.13E-13 |
| 3 | Golgi vesicle transport | GO:0048193 | 79 | 2.83E-22 |
| 4 | G protein-coupled receptor activity | GO:0004930 | 108 | 1.75E-22 |
| 5 | peptide metabolic process | GO:0006518 | 90 | 4.37E-31 |
| 6 | canonical Wnt signaling pathway | GO:0060070 | 75 | 2.17E-27 |
| 7 | glycerophospholipid metabolic process | GO:0006650 | 51 | 8.98E-22 |
| 8 | nucleotide biosynthetic process | GO:0009165 | 38 | 5.50E-11 |
| 9 | ephrin receptor signaling pathway | GO:0048013 | 36 | 6.05E-17 |
| 10 | regulation of cellular macromolecule biosynthetic process | GO:2000112 | 43 | 5.09E-08 |
| 11 | aromatic compound biosynthetic process | GO:0019438 | 50 | 3.61E-08 |