Table 1.
Genes with Most Frequent Lentiviral (LV)-Fah Integration
| Lymph Node Hepatocytes | Liver Hepatocytes | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| TopGenes | Number of IntegrationSites | Percent of IntegrationSites | Numberof Reads | Percentof Reads | TopGenes | Number of IntegrationSites | Percent of IntegrationSites | Numberof Reads | Percentof Reads | Enrichment |
| GLRX2 | 26 | 0.40 | 338,309 | 25.57 | MIR9799 | 18 | 0.41 | 5,479,826 | 56.29 | 5.00 |
| MIR9799 | 14 | 0.21 | 148,852 | 11.25 | NDUFV2 | 53 | 1.20 | 1,669,810 | 17.15 | 5.76 |
| LNPK | 53 | 0.81 | 146,239 | 11.05 | IFRD1 | 45 | 1.02 | 952,259 | 9.78 | 5.81 |
| PDCD10 | 81 | 1.24 | 129,982 | 9.82 | SUCLG1 | 24 | 0.54 | 707,921 | 7.27 | 5.06 |
| BEX1 | 51 | 0.78 | 41,620 | 3.15 | CENPP | 77 | 1.75 | 328,807 | 3.38 | 78.69 |
| NDUFV2 | 25 | 0.38 | 39,429 | 2.98 | GPX2 | 36 | 0.82 | 78,896 | 0.81 | 5.63 |
| IDO1 | 5 | 0.08 | 30,360 | 2.29 | CTDSP2 | 45 | 1.02 | 41,364 | 0.42 | 13.71 |
| FAH | 206 | 3.15 | 28,545 | 2.16 | RAB28 | 19 | 0.43 | 23,253 | 0.24 | 6.03 |
| IFRD1 | 31 | 0.47 | 22,270 | 1.68 | QKI | 7 | 0.16 | 16,777 | 0.17 | 5.44 |
| BMP5 | 35 | 0.54 | 19,409 | 1.47 | GSTO1 | 21 | 0.48 | 14,074 | 0.14 | 7.22 |
| MTRF1 | 65 | 0.99 | 19,077 | 1.44 | ENY2 | 30 | 0.68 | 12,470 | 0.13 | 3.97 |
| SUCLG1 | 10 | 0.15 | 19,033 | 1.44 | PRMT6 | 26 | 0.59 | 12,390 | 0.13 | 0.25 |
| ADAMTS1 | 17 | 0.26 | 17,754 | 1.34 | C1QTNF3 | 49 | 1.11 | 11,544 | 0.12 | 1.44 |
| HSD17B3 | 35 | 0.54 | 16,484 | 1.25 | RGS5 | 13 | 0.30 | 11,377 | 0.12 | 2.02 |
| SLC9A2 | 8 | 0.12 | 14,970 | 1.13 | MTRF1 | 36 | 0.82 | 10,972 | 0.11 | 0.08 |
| ACVR2A | 53 | 0.81 | 13,296 | 1.00 | SNCAIP | 5 | 0.11 | 10,252 | 0.11 | 0.81 |
| KCNJ2 | 5 | 0.08 | 12,294 | 0.93 | CTSV | 5 | 0.11 | 9,865 | 0.10 | 5.34 |
| CLDN22 | 32 | 0.49 | 12,073 | 0.91 | FAH | 135 | 3.06 | 9,650 | 0.10 | 0.05 |
Enrichment was calculated as the percent of reads in the liver population divided by the percent of reads in the lymph node population of hepatocytes by gene.