Gene Co-expression Analysis of Human SN Identifies STRAP and NME1 Co-expression with Multiple Markers of Midbrain Dopaminergic Neurons
(A and B) Linear regression showing the correlation between (A) STRAP and (B) NME1 and three markers of midbrain dopaminergic neurons (TH, GIRK2, ALDH1A1) in the human SN (n = 101). The r and Bonferroni-corrected p values are shown on each graph. Raw data were derived from dataset GSE60863 from the Gene Expression Omnibus and analyzed using the R2 microarray platform.
(C) Table showing the number of genes in the human SN displaying a multiple testing-adjusted correlation of ≥0.7 with STRAP (n = 948) and NME1 (n = 1,586), along with a GO enrichment analysis of these gene lists. The top two GO categories based on fold-enrichment in each gene list are shown, along with the fold-enrichment and false discovery rate (FDR)-adjusted p value.