Table 1.
Hemodynamic and Other Group Data
| Sham MI |
Post-MI |
|||
|---|---|---|---|---|
| shamVNS (n = 8) | optoVNS (n = 9) | shamVNS (n = 9) | optoVNS (n = 12) | |
| Body weight (g) | 431 ± 18 | 406 ± 29 | 453 ± 18 | 391 ± 5 |
| Infarct size | — | — | 34.9 ± 0.7 | 33.2 ± 0.8 |
| HR (beats/min, under isoflurane) | 348 ± 9 | 380 ± 12 | 364 ± 12 | 389 ± 12 |
| Ejection fraction (%) | 49.6 ± 5.1 | 76.3 ± 2.3 | 32.7 ± 3.0 | 49.3 ± 3.3 |
| E/A ratio | 1.2 ± 0.1 | 1.6 ± 0.1 | 0.9 ± 0.1 | 1.2 ± 0.1 |
| HR (beats/min, under urethane) | 371 ± 15 | 380 ± 19 | 363 ± 19 | 380 ± 13 |
| dP/dtmin (mm Hg/s) | −6,136 ± 269 | −6,774 ± 391 | −4,348 ± 275 | −5,550 ± 176 |
| Pulse pressure (mm Hg) | 52 ± 4 | 51 ± 2 | 36 ± 4 | 51 ± 5 |
| LV to body weight ratio | 2.12 ± 0.07 | 1.92 ± 0.06 | 2.19 ± 0.08 | 2.24 ± 0.05 |
| RV to body weight ratio | 0.38 ± 0.01 | 0.37 ± 0.01 | 0.42 ± 0.02 | 0.36 ± 0.02 |
| Lung fluid (%) | 77.5 ± 0.3 | 77.8 ± 0.5 | 77.3 ± 0.3 | 78.4 ± 0.3 |
Values are mean ± SEM.
dP/dtmin = maximum rate of left ventricular pressure decrease; HR = heart rate; LV = left ventricle; MI = myocardial infarction; RV = right ventricle; VNS = vagus nerve stimulation.