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. 2020 Jul 31;23(9):101426. doi: 10.1016/j.isci.2020.101426

Figure 3.

Figure 3

Thymic Stromal Cells Require Vitamin B1 to Inhibit Excessive Production of the TGF-β Superfamily In Vivo

(A) The levels of Gdf10, Inhba, and Tgfb2 mRNAs in thymic stromal cells after 3 weeks of feeding mice a vitamin B1-deficient diet (VB1–) or control diet (Con). Horizontal lines indicate median values. p values were obtained by using the Mann-Whitney U-test (∗p < 0.05). The data shown are reproducible and representative of two independent experiments.

(B) FACS plots showing the ratios of cells positive for phosphorylated smad2, smad3+, and CD8α+ among TCRγδ+ thymocytes from VB1– and Con mice. Horizontal lines indicate median values. p values were obtained by using the Mann-Whitney U-test (∗p < 0.05).