Table 1.
Molecular events regulating EMT in the pathogenesis of OSF and OSCC.
| OSF | OSCC | |
|---|---|---|
| Epithelial markers | • ↓ E –cadherin (membranous loss) (CDH1) [20] | • ↓ E –cadherin (membranous loss) (CDH1) [43,139] |
| • ↓ Cytokeratin 5, 14 (CK5, CK14) (KRT 5, 14) [21] | • ↑ Cytokeratin 5, 14 (CK5, CK14) (KRT 5, 14) [140] | |
| Mesenchymal markers | • ↑Vimentin (VIM) [22] | • ↑ Vimentin (VIM) [69] |
| • ↑N- cadherin (CDH2) [11] | • ↑ N- Cadherin (CDH2) [139] | |
| • ↑Alpha Smooth muscle Actin (α-SMA)(ACTA2) [42] | • ↑Alpha Smooth muscle Actin (α-SMA)(ACTA2) [141] | |
| Transcription factors | • ↑ SNAI-1 [142] | • ↑ SNAI-1 [143], SNAI-2 [144] |
| • ↑ Twist [11,37] | • ↑ Twist [41] | |
| • ↑ ZEB1 [23] | • ↑ ZEB1 [43] | |
| • ↑ LEF-1 [48] |