Table 1.
Animal models of spine surgery pertaining to disc degeneration.
| SNo. | Author Name | Animal used | Specific models and/or Techniques used |
|---|---|---|---|
| 1 | J. Sahlman(J. Sahlman22 et al., 2001) | Mice | heterozygous knockout of Col2a1 gene |
| 2 | C. W. Goff (C. W. Goff23 et al., 1957) | Rats and mice | Bipedal animals |
| 3 | M. Higuchi (M. Higuchi19 et al., 1983) | Mice | Changes in the nucleus pulposus of the intervertebral disc |
| 4 | K. Masuda (K. Masuda24et al., 2005) | Rabbit | reproducible disc degeneration by an annulus needle puncture |
| 5 | T. Miyamoto (T. Miyamoto25 et al., 2010) | Rabbit | Intradiscal transplantation of synovial mesenchymal stem cells |
| 6 | M. W. Kroeber (M. W. Kroeber26et al., 2002) | Rabbit | Intervertebral disc compression by percutaneous approach |
| 7 | N. A. Gillett (N. A. Gillett27et al., 1988) | Canine | radiology, histology, and mechanical testing |
| 8 | K. Serigano (K. Serigano et al., 2010) | Canine | mesenchymal stem cell transplantation |
| 9 | N. Bergknut (N. Bergknut28 et al., 2012) | Canine | chondrodystrophic (CD) and nonchondrodystrophic dogs (NCD) translational model for human IVDD research. |
| 10 | Y. Zhang (Y. Zhang29et al., 2011) | Goat | optimal method for inducing goat IVD degeneration |
| 11 | R. J. W. Hoogendoorn(R. J. W. Hoogendoorn14et al., 2008) | Goat | Chondroitinase ABC (CABC) induced goat model |
| 12 | T. H. Smit (T. H. Smit15et al., 2002) | Goat | Biomechanical analysis |
| 13 | R. J. W. Hoogendoorn(R. J. W. Hoogendoorn et al., 2005) | Goat | absence of notochordal cells |
| 14 | C. J. Hunter (C. J. Hunter et al., 2004) | Sheep | comparing the cytomorphology of the nucleus pulposus in mammals commonly used in laboratory |
| 15 | H. J. Wilke (H. J. Wilke16 et al., 1997) | Sheep | quantitative biomechanical properties of the sheep spine and compare with human spine |
| 16 | O. L. Osti (O. L. Osti17 et al., 1990) | Sheep | Peripheral tears of the annulus fibrosus |
| 17 | J. Melrose (J. Melrose29et al., 2012) | Sheep | IVD mechanical destabilization on matrix protein and metalloproteinase gene expression to investigate the pathophysiological mechanisms of lumbar IVDD. |
| 18 | D. Oehme22 (D. Oehme et al., 2014) | Sheep | Pentosapolysulfate with mesenchymal progenitor cells |
| 19 | T. Goldschlager23 (T. Goldschlager et al., 2011) | Sheep | Allogenic mesenchymal precursor cells combined with hydroxyapatite and tricalcium phosphate (HA/TCP) with HA/TCP alone or iliac crest autograft (AG) for cervical interbody fusion |
| 20 | T. Goldschlager24 (T. Goldschlager et al., 2011) | Sheep | To compare the capacity of MPCs and AECs in an ovine model. |
| 21 | T. Goldschlager 25(T. Goldschlager et al., 2010) | Sheep | using MPCs in combination with PPS to produce cartilaginous tissue to replace the intervertebral disc following ACD |
| 22 | F. L. Acosta (F. L. Acosta32et al., 2011) | Porcine | Nucleotomy for IVD deegeneration |
| 23 | G. W. Omlor (G. W. Omlor33et al., 2009) | Goettingenminipigs | Disc remodeling and degeneration after nucleotomy |
| 24 | R. C. Platenberg (R. C. Platenberg34et al., 2001) | Baboon | Spontaneous disc degeneration baboon model |
| 25 | D. J. Nuckley (D. J. Nuckley35 et al., 2008) | Primates | Natural disc degeneration |
| 26 | W. E. Stern (W. E. Stern36et al., 1976) | rhesus monkeys | Collagenase induced IVD degeneration |
| 27 | F. Wei (F. Wei37 et al., 2014) | rhesus monkeys | slowly progressive and reproducible intervertebral disc (IVD) degeneration model by Bleomycin |