Table 1.

Detailed information of instrumental variables for TNF levels.

rsID	Chr	Position (hg19)	Nearby gene	EA	NEA	EAF	Beta	SE	P	Included in main analysis
rs2857602	6	31,533,378	LTA	G	A	0.38	0.032	0.006	3.30 × 10−12	No
rs10744774	12	112,090,022	BRAP	A	C	0.83	0.044	0.007	6.94 × 10−11	Yes
rs3184504	12	111,884,608	SH2B3	T	C	0.48	0.030	0.005	3.96 × 10−10	Yes
rs7182229	15	58,765,183	LIPC	T	G	0.11	0.050	0.009	1.07 × 10−9	Yes

Chr indicates chromosome; EA; effect allele; EAF, effect allele frequency; NEA, non-effect allele; SE, standard error; TNF, tumour necrosis factor. Rs2857602 was not included in the main analysis since the TNF-increasing allele was associated with lower odds of rheumatoid arthritis and inflammatory bowel disease.