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. 2020 Aug 2;23(8):101431. doi: 10.1016/j.isci.2020.101431

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Immune Landscape of BxPC-3-Derived sEVs-Treated T Lymphocytes

(A) tSNE plot showing the differences in distributions of the Ctrl-T and sEVs-T.

(B) tSNE plot showing a total of 37 clusters and the distributions in clusters of the Ctrl-T and sEVs-T.

(C) Heatmap showing the differential expressions of 42 immune markers in the 37 cell clusters. The label on the left showing the T cell types of clusters according to typically expressed markers.

(D) Heatmap (top) showing the differential expressions of 42 immune markers between Ctrl-T and sEVs-T (n = 5). Box plot (bottom) showing the differential expressions of 8 immunosuppressive biomarkers between Ctrl-T and sEVs-T (n = 5). Data derived from CyTOF. Data shown are mean ± standard deviation. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001 (two-tailed, unpaired Student's t test).