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. 2020 Aug 2;23(8):101431. doi: 10.1016/j.isci.2020.101431

Figure 9.

Figure 9

The Expressions of FOXO1A, FOXO3A, and FOXP3 in PDAC Lymph Node

(A) Left scatterplots showing the correlation between FOXO1A and Treg abundance. Right scatterplots showing the correlation between FOXO3A and Treg abundance. Data derived from the TISIDB (http://cis.hku.hk/TISIDB/).

(B) Immunohistochemistry (IHC) images showing the FOXO1A expression in normal and metastatic lymph nodes. Arrowhead indicating the positive expression. Scale bar indicated in image.

(C) Quantification of (B) showing the average IHC score of FOXO1A in 20 paired normal and metastatic lymph nodes under 40× objective.

(D) Immunohistochemistry images showing the FOXO3A expression in normal and metastatic lymph nodes. Arrowhead indicating the positive expression. Scale bar indicated in image.

(E) Quantification of (D) showing the average IHC score of FOXO3A in 20 paired normal and metastatic lymph nodes under 40× objective.

(F) Immunohistochemistry images showing the FOXP3 expression in normal and metastatic lymph nodes. Arrowhead indicating the positive expression. Scale bar indicated in image.

(G) Quantification of (F) showing the average IHC score of FOXP3 in 20 paired normal and metastatic lymph nodes under 40× objective.

(H) Left scatterplots showing the correlation between FOXO1A and FOXP3. Right scatterplots showing the correlation between FOXO3A and FOXP3. Data derived from (A, C, and E).

(A) R value meaning correlation coefficient, p < 0.05 meaning statistically significant (Spearman's correlation). (C, E, and G) Data shown are mean ± SD. ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001 (n = 20, paired t test). (H) R value meaning correlation coefficient (n = 40, including 20 normal lymph nodes and 20 metastatic lymph nodes), p < 0.05 meaning statistically significant (Pearson's correlation).