Fig. 7.

IFNα modulates the NK cell-surface glycome. (A) Heat-map depicting normalized lectin-binding intensity of NK cell-surface proteins isolated from NK cells before and five weeks during Peg-IFNα2a treatment. Heat colors show standardized Z-scores; red indicates higher binding, and blue indicates lower binding. Top half lists glycan structures whose levels decreased by IFNα treatment, bottom half lists glycan structures whose levels increased by IFNα treatment. Wilcoxon signed-rank tests. Nominal p values and corrected FDR are displayed. (B) Correlation heat-map showing associations between IFNα2a-mediated changes on the NK cell glycomes and K652-stimulated NK cell phenotypes. The size and colour of circles represent the strength of correlation, with blue shades representing negative correlations, and red shades representing positive correlations. Correlations were evaluated using Spearman's rank correlation tests. *=P < 0.05, and **=P < 0.01. N = 8. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)