Table 2.

Molecular characteristics of PARP inhibitor sensitive cell lines

	MSI status	TP53	CMS	HRD score	Biallelic aberration HR gene1	No. of mutated HR genes2	PARPi sensitivity score3
SKCO1	MSS	wt	CMS3	50	ATM	1	-0.37
LS513	MSS	wt	CMS3	9	No	4	0.06
COLO205	MSS	mut	n.a.	42	No	1	-0.16
HCT116	MSI	wt	CMS4	17	MSH3	32	0.42
HROC87	MSI	n.a.	CMS1	n.a.	n.a.	n.a.	n.a.
MDST8	MSS	wt	CMS4	21	PTEN, REV3L	6	0.1
LS174T	MSI	wt	CMS3	22	No	23	0.06
SW48	MSI	wt	n.a.	7	No	23	0.45

¹Genes harbouring homozygous mutations, biallelic deletions or mutations in the single remaining allele included. 133 genes implicated in homologous recombination and/or PARP inhibitor sensitivity have been investigated.

²See Supplementary Table S7 for full list of mutations in relevant genes

³Gene expression-based signature of PARP inhibitor sensitivity

HR: homologous recombination, n.a.; not available, mut; mutated, PARPi; PARP inhibitor wt; wild-type