Table 2.
Univariate Cox analysis of TNF family genes in TCGA Cohort.
| Official symbol | Aliases | Family | HR | 95%CI | P value |
|---|---|---|---|---|---|
| CD27 | TNFRSF7 | TNFRSF | 0.8682 | 0.7858-0.9592 | 0.0055 |
| CD40 | TNFRSF5 | TNFRSF | 0.9089 | 0.8063-1.0246 | 0.1182 |
| CD40LG | TNFSF5, CD154 | TNFSF | 0.8194 | 0.7421-0.9049 | 0.0000 |
| CD70 | TNFSF7, CD27L | TNFSF | 1.0688 | 0.9757-1.1708 | 0.1522 |
| EDA | EDA-A1, EDA-A2 | TNFSF | 0.9561 | 0.8727-1.0474 | 0.3345 |
| EDA2R | TNFRSF27, XEDAR | TNFRSF | 0.9107 | 0.8387-0.9888 | 0.0259 |
| EDAR | EDA-A1R | TNFRSF | 1.0425 | 0.9744-1.1154 | 0.2275 |
| FAS | TNFRSF6, CD95 | TNFRSF | 0.9501 | 0.8396-1.0752 | 0.4176 |
| FASLG | TNFSF6, CD95-L | TNFSF | 0.9083 | 0.8204-1.0056 | 0.0641 |
| LTA | TNFSF1 | TNFSF | 0.8918 | 0.8002-0.9939 | 0.0385 |
| LTB | TNFSF3 | TNFSF | 0.8771 | 0.7949-0.9679 | 0.0091 |
| LTBR | TNFRSF3 | TNFRSF | 1.3077 | 1.0591-1.6147 | 0.0126 |
| NGFR | TNFRSF16, CD271 | TNFRSF | 1.0011 | 0.9123-1.0986 | 0.9808 |
| RELT | TNFRSF19L | TNFRSF | 0.9259 | 0.7884-1.0873 | 0.3477 |
| TNF | TNFSF2, TNFA | TNFSF | 0.9098 | 0.8257-1.0024 | 0.0560 |
| TNFRSF10A | TRAILR1, CD261 | TNFRSF | 1.0582 | 0.9025-1.2408 | 0.4858 |
| TNFRSF10B | TRAILR2, CD262 | TNFRSF | 1.0336 | 0.8482-1.2596 | 0.7428 |
| TNFRSF10C | TRAILR3, CD263 | TNFRSF | 0.8628 | 0.7727-0.9634 | 0.0087 |
| TNFRSF10D | TRAILR4, CD264 | TNFRSF | 1.0799 | 0.9334-1.2495 | 0.3015 |
| TNFRSF11A | RANK, CD265 | TNFRSF | 1.1316 | 0.9925-1.2902 | 0.0647 |
| TNFRSF11B | OPG | TNFRSF | 1.0088 | 0.9139-1.1135 | 0.8619 |
| TNFRSF12A | FN14, TWEAKR, CD266 | TNFRSF | 1.1040 | 0.9768-1.2477 | 0.1131 |
| TNFRSF13B | TACI, TNFRSF14B, CD267 | TNFRSF | 0.8682 | 0.7987-0.9438 | 0.0009 |
| TNFRSF13C | BAFFR, CD268 | TNFRSF | 0.8788 | 0.7977-0.9682 | 0.0090 |
| TNFRSF14 | LIGHTR, HVEM, CD270 | TNFRSF | 0.8253 | 0.7112-0.9577 | 0.0114 |
| TNFRSF17 | BCMA, TNFRSF13A, CD269 | TNFRSF | 0.9023 | 0.8370-0.9727 | 0.0073 |
| TNFRSF18 | GITR, AITR, CD357 | TNFRSF | 0.9919 | 0.9060-1.0860 | 0.8607 |
| TNFRSF19 | TROY, TAJ | TNFRSF | 0.8596 | 0.7735-0.9553 | 0.0050 |
| TNFRSF1A | TNFR1, CD120A | TNFRSF | 1.3583 | 1.0542-1.7500 | 0.0179 |
| TNFRSF1B | TNFR2, CD120B | TNFRSF | 0.8640 | 0.7360-1.0142 | 0.0739 |
| TNFRSF21 | DR6, CD358 | TNFRSF | 1.1041 | 0.9425-1.2935 | 0.2201 |
| TNFRSF25 | DR3, TNFRSF12 | TNFRSF | 0.9262 | 0.8376-1.0241 | 0.1349 |
| TNFRSF4 | OX40, CD134 | TNFRSF | 0.9510 | 0.8323-1.0867 | 0.4607 |
| TNFRSF6B | DCR3 | TNFRSF | 1.1399 | 1.0481-1.2397 | 0.0022 |
| TNFRSF8 | CD30 | TNFRSF | 0.9513 | 0.8343-1.0847 | 0.4560 |
| TNFRSF9 | 4-1BB, CD137, ILA | TNFRSF | 0.9837 | 0.9007-1.0744 | 0.7156 |
| TNFSF10 | TRAIL, CD253 | TNFSF | 0.9741 | 0.8621-1.1007 | 0.6740 |
| TNFSF11 | RANKL, CD254 | TNFSF | 1.0685 | 0.9942-1.1484 | 0.0717 |
| TNFSF12 | TWEAK | TNFSF | 0.7643 | 0.6331-0.9226 | 0.0051 |
| TNFSF13 | APRIL, CD256 | TNFSF | 0.7978 | 0.6847-0.9296 | 0.0038 |
| TNFSF13B | BAFF, CD257 | TNFSF | 0.9889 | 0.8846-1.1056 | 0.8448 |
| TNFSF14 | LIGHT, HVEML, CD258 | TNFSF | 1.0094 | 0.9061-1.1246 | 0.8648 |
| TNFSF15 | TL1A | TNFSF | 0.9212 | 0.8391-1.0113 | 0.0848 |
| TNFSF18 | GITRL | TNFSF | 0.8992 | 0.7838-1.0316 | 0.1296 |
| TNFSF4 | OX-40L, CD134L, CD252 | TNFSF | 1.0323 | 0.9090-1.1723 | 0.6246 |
| TNFSF8 | CD30L, CD153 | TNFSF | 0.8864 | 0.7979-0.9848 | 0.0247 |
| TNFSF9 | 4-1BB-L, CD137L | TNFSF | 1.0888 | 0.9787-1.2112 | 0.1177 |
TCGA, The Cancer Genome Atlas; HR, hazard ratio; CI, confidence interval.