Fig. 3.

TRIM7 regulates osteosarcoma cells’ response to chemotherapy. (a) After 21 days of intravenous injection with MG63 or SAOS2 cells as well as intraperitoneal injection with 1 mg/kg ADR, 0.2 mg/kg MTX, or vehicle (n = 5), a histological inspection was measured by H&E. Scale bar: 200 μm. (b) The survival period of the mice from each group is shown (n = 15). The statistical analysis was performed using Log-rank (Mantel-Cox) test. (c) Tumour weight was measured in mice with the patient-derived xenograft (PDX) following ADR or MTX chemotherapy (n = 5). P < 0.05, P < 0.01, P < 0.001 (one-way ANOVA followed by Bonferroni post-tests). All the experiments were repeated at least three times, and data are represented as mean ± SD.