Figure 3.

NR (1000 mg/kg) treatment preserves retinal function in LIRD mice. Representative ERG waveforms (A) of one eye of a single mouse from each treatment group. Scotopic ERG a-wave (B) and b-wave (C) mean amplitudes from LIRD mice at 1 week after LIRD induction. Mice treated with PBS and exposed to 3000-lux light for 4 hours to induce degeneration exhibited a- and b-wave mean amplitudes (red) that were statistically significantly diminished compared with those of dim groups (blue and black). However, the mean ERG amplitudes of mice undergoing retinal degeneration and treated with NR (green) were statistically indistinguishable from those treated with PBS and exposed to bright light. ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001 versus other groups by two-way ANOVA with Newman-Keuls multiple comparisons post hoc test. N = 4–6 mice per group. Error bars represent SEM.