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. 2020 Aug 27;22(5):115. doi: 10.1208/s12248-020-00500-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Observed International Prostate Symptom Scores (IPSS) vs. item response theory disability estimates from the unidimensional item response theory model based on 3117 separate measurements from 403 patients over the 6-month trial period. b Observed change from baseline in International Prostate Symptom Scores (IPSS) vs. change from the baseline of item response theory disability from the unidimensional item response theory model in 403 patients over the 6-month trial period. MDD minimally detectable difference