Fig. 3.

Nonsplicing roles of the SF3b complex. The SF3b complex and its components participate in various molecular and cellular events that are beyond its canonical role in splicing. These events are sorted as either U2-dependent (labeled with circled numbers, ② for the 3′-end processing of histone pre-mRNA [81], ③ for PcG-mediated Hox gene repression [84] and ④ for the inhibition of AAV vector transduction [93]) or U2-independent (⑤ for novel mRNA export pathway mediated by THO [83]) for the SF3b complex in the nucleus. SF3b components are also engaged in several biological events that occur in different cellular compartments (⑥ for SF3b3 and SF3b5 containing the SAGA complex [96, 97, 99], ⑦ for SF3b1 containing the B-WICH complex [101], ⑧ for SF3b3 containing CRLs [102, 103], ⑨ for the SF3b4-p180 complex in ER translational control [104], and ⑩ for the SF3b3-Mincle-mediated inflammatory response in necrotic cells [111]). The splicing pathway of the SF3b complex (labeled with ①) is also depicted for completeness and comparison