Table 2.
Summary of the conserved regions identified in the S1 and S2 subunits of the Spike protein. Only conserved clusters comprised by a minimum of 10 aa and with a conserved score ≥ 7 were considered for either the hSARSr-CoVs, the SARSr-CoVs (including the bat-SL-CoVs) and the SARSr- and MERSr-CoVs. Regions common to all three groups are highlighted in bold and blue.
|
human SARSr-CoV |
SARSr-CoV |
SARSRr- and MERSr-CoV |
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
S1 subunit |
S2 subunit |
S1 subunit |
S2 subunit |
S1 subunit |
S2 subunit |
||||||||||||
| Region | Position | Lenght (aa) | Region | Position | Lenght (aa) | Region (analogue to the hSARSr-CoVs) | Position | Lenght (aa) | Region | Position | Lenght (aa) | Region (analogue to the hSARSr-CoVs) | Position | Lenght (aa) | Region | Position | Lenght (aa) |
| NTD.1 | T51-T63 | 13 | NTD.1 | S691-E702 | 12 | NTD.1 | T51-T63 | 13 | S2-NTD.1 | S691-E702 | 12 | NTD.4 | V308-V320 | 13 | sv-CR.1 | I818-K835 | 18 |
| NTD.2 | T95-G107 | 13 | NTD.2 | M740-C749 | 10 | NTD.2 | T95-G107 | 13 | S2-NTD.2 | M740-C749 | 10 | RBD.3 | S373-L390 | 17 | sv-CR-HR1.1 | Y904-Q913 | 10 |
| NTD.3 | T274-C291 | 18 | NTD.3 | N751-L767 | 17 | A262-P272 | 11 | S2-NTD.3 | N751-L767 | 17 | SD1.1 | C538-T553 | 16 | sv1-HR1-CH.1 | L966-S975 | 11 | |
| NTD.4 | V308-V320 | 13 | FP.1 | F797-P809 | 13 | NTD.3 | T274-C291 | 18 | FP.1 | F797-P809 | 13 | SD2.4 | S659-A672 | 14 | sv2-HR1-CH.1 | E990-L1001 | 12 |
| RBD.1 | I326-F347 | 22 | CR.1 | K814-F833 | 20 | NTD.4 | V308-V320 | 13 | CR.1 | K814-F833 | 20 | – | – | sv3-HR1-CH.1 | T1006-A1015 | 10 | |
| RBD.2 | R355-A372 | 18 | CR.2 | K835-I844 | 10 | RBD.1 | I326-F347 | 22 | CR.2 | K835-I844 | 10 | – | – | sv1-CD-HR2.1 | S1147-N1158 | 12 | |
| RBD.3 | F374-S383 | 10 | CR.3 | A846-A871 | 26 | RBD.2 | R355-A372 | 18 | CR.3 | A846-A871 | 26 | – | – | sv2-CD-HR2.1 | K1211-M1229 | 19 | |
| RBD.4 | N394-G416 | 23 | CR-HR1.1 | G885-K921 | 37 | RBD.3 | RBD.4 | F374-G416 | 43 | CR-HR1.1 | G885-N928 | 43 | ||||||
| RBD.5 | I418-F429 | 12 | HR1-CH.1 | A944-Q1054 | 111 | RBD.5 | I418-F429 | 12 | HR1-CH.1 | A944-Q1054 | 111 | ||||||
| RBD.6 | G502-L518 | 17 | CH.1 | A1056-P1069 | 14 | RBD.6 | G502-L518 | 17 | CH.1 | A1056-P1069 | 14 | ||||||
| SD1.1 | S530-T553 | 24 | CH-CD.1 | Q1071-V1096 | 26 | SD1.1 | L533-T553 | 21 | CH-CD.1 | Q1071-V1096 | 26 | ||||||
| SD2.1 | P589-S605 | 17 | CD-HR2.1 | P1112-I1232 | 121 | SD2.1 | P589-S605 | 17 | CD-HR2.1 | P1112-I1232 | 121 | ||||||
| SD2.2 | A623-G639 | 17 | HR2-CP.1 | L1234-G1246 | 13 | SD2.2 | A623-G639 | 17 | HR2-CP.1 | L1234-G1246 | 13 | ||||||
| SD2.3 | N641-N657 | 17 | CP.1 | C1248-T1273 | 26 | SD2.3 | N641-N657 | 17 | CP.1 | C1248-T1273 | 26 | ||||||
| SD2.4 | S659-T676 | 18 | – | – | – | SD2.4 | S659-T676 | 18 | – | – | – | ||||||