Skip to main content
. 2020 Apr 10;11(9):661–679. doi: 10.1007/s13238-020-00713-x

Figure 1.

Figure 1

Bmal1 deletion caused dilated cardiomyopathy in mice. (A) Histological analyses of heart sections of wild type and Bmal1 KO mice by H&E staining at 32 weeks of age. Scale bar: 1 mm. (B) Statistics of the average thickness of IVS and LVPW of wild type and Bmal1 KO mice (n = 4). *P < 0.05 and **P < 0.01 versus control by two-tailed Student’s t test. (C) Representative confocal microscopy images of WGA staining of myocardium from wild type and Bmal1 KO mice. (D) Quantification of cell surface area as shown in (C) (n = 59 per group). ****P < 0.0001 versus control by two-tailed Student’s t test. (E) Representative electron micrographs of ventricular cardiomyocytes from wide type and Bmal1 KO mice. Red arrows indicate Z-lines. (F) Representative echocardiography images of 32-weeks-old wild type and Bmal1 KO mice. (G–N) Echocardiographic parameters of heart functions from wild type and Bmal1 KO mice over time (n = 4 per group). 2-way ANOVA with post-hoc tes. Data were represented mean ± SD. *P < 0.05 and **P < 0.01 versus control by 2-way ANOVA with post-hoc test