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. 2020 Apr 10;11(9):661–679. doi: 10.1007/s13238-020-00713-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Multi-electrode array analyses of electrophysiology of BMAL1 KO hESC-derived cardiomyocytes. (A) hESC-derived cardiomyocytes day 35 post differentiation cultured on a MEA probe coated with matrigel. Scale bar: 200 μm. (B) Typical field potential traces of hESC-derived cardiomyocytes recorded by MEA. (C) Representative MEA recordings showed field potential traces from wild type and BMAL1 KO hESC-derived cardiomyocytes day 35 post differentiation. (D) Quantification of beating frequency of wild type and BMAL1 KO hESC-derived cardiomyocytes in response to epinephrine and metoprolol. Data were represented as mean ± SD. The statistics were from 3 independent experiments. *P < 0.05 and **P < 0.01 versus control by two-tailed Student’s t test