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The regulatory mechanism of BMAL1 in mitophagy of cardiomyocyte and DCM. Our study demonstrated that BMAL1 is able to bind to the E-box element in the promoter region of BNIP3 gene and specifically control BNIP3 protein expression, hence directly affecting the BNIP3-mediated mitochondria quality control process. The circadian gene Bmal1 is critical in the maintenance of normal mitochondria activities and cardiac function
