Table 1.
Characteristics of AREDS and AREDS2 participants.
| Characteristics | AREDS | AREDS2 |
|---|---|---|
| Participants characteristics | ||
| Number of participants | 2177 | 1121 |
| Age, mean (SD), y | 68.4 (4.8) | 70.9 (7.9) |
| Smoking history (never, former, current), % | 49.6/45.6/4.8 | 45.9/48.5/5.5 |
| CFH rs1061170 (TT/CT/CC), % | 33.3/46.4/20.3 | 17.8/41.7/40.5 |
| ARMS2 rs10490924 (GG/GT/TT), % | 55.2/36.5/8.3 | 40.5/42.8/16.7 |
| AMD Genetic Risk Score, mean (SD) | 14.2 (1.4) | 15.2 (1.3) |
| Follow-up, median (IQR), y | 10.0 (3.0) | 5.0 (2.0) |
| Progression to late AMD (classified by Reading Center) | ||
| Late AMD: % of participants at year 1/2/3/4/5/all years | 1.5/3.9/6.68/8.6/10.7/18.5 | 9.1/16.2/23.8/32.6/38.1/38.8 |
| GA: % of participants at year 1/2/3/4/5/all years | 0.6/1.5/2.8/4.0/5.1/10.1 | 4.8/9.0/13.0/17.8/20.8/21.0 |
| NV: % of participants at year 1/2/3/4/5/all years | 0.9/2.4/4.0/4.6/5.5/8.4 | 4.3/7.2/10.8/14.7/17.3/17.8 |
The AREDS contained a wide spectrum of baseline disease severity, from no age-related macular degeneration (AMD) to high-risk intermediate AMD. The AREDS2 contained a high level of baseline disease severity, i.e., high proportion of eyes at high risk of progression to late AMD.
SD standard deviation, y year, IQR interquartile range, AMD age-related macular degeneration.