Table 4.
The 5-year C-statistic (95% CI) results of models trained on the entire AREDS and tested on the entire AREDS2 (1121 participants), without using genotype information.
| Models | Tested on the entire AREDS2 |
|---|---|
| Late AMD | |
| Deep features/survival | 71.0 (70.2,71.7) |
| DL grading/survival | 69.7 (68.9,70.5) |
| Retinal specialists/calculator | 63.9 (63.2,64.6) |
| Retinal specialists/SSSa | 62.5 (62.3,62.7) |
| Geographic atrophy | |
| Deep features/survival | 75.3 (74.5,76.0) |
| DL grading/survival | 75.0 (74.0,76.0) |
| Retinal specialists/calculator | 64.4 (63.6,65.2) |
| Retinal specialists/SSSa | – |
| Neovascular AMD | |
| Deep features/survival | 62.8 (61.9,63.8) |
| DL grading/survival | 61.8 (61.0,62.7) |
| Retinal specialists/calculator | 61.8 (60.8,62.9) |
| Retinal specialists/SSSa | – |
aRetinal specialists/SSS—makes predictions at one fixed interval of 5 years and for late AMD only (i.e., not by disease subtype); unlike all other models, for SSS, late AMD is defined as NV or central GA (instead of NV or any GA).