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. 2020 Aug 27;11(8):710. doi: 10.1038/s41419-020-02900-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis (a) and Gene set variation analysis (GSVA) (b) were conducted in TCGA dataset to explore PGAM1-related downstream pathways. c–e GSEA analysis the enrichment of the TGF-β signaling pathway related genesets in NSCLC tissues with different PGAM1 expression level. Expression levels of TGF-β, BMP4, ICAM1 and VCAM1 in A549 cells transfected with shCtrl or shPGAM1 were analyzed by real-time PCR (f), western blot (g) in vitro. h The xenografts were embedded in paraffin blocks and paraffin sections were examined by IHC staining. Scale bars, 100 μm. *p < 0.05, **p < 0.01.