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. 2020 Aug 24;9(9):37. doi: 10.1167/tvst.9.9.37

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Figure 2. — The iC3b generation. FI functional activity is ascertained by the quantity of iC3b generated as determined by ELISA. (A) Individual values are shown as solid green circles for AAMD and purple circles for those without AAMD. Black horizontal line represents mean iC3b value for controls. (B) Box plots demonstrate that both type 1 (P < 4E-08, compared with no AMD and no variant; P < 4E-08, compared with AMD and no variant) and type 2 variants (P < 0.0005, compared with no AMD and no variant; P < 4E-08, compared with AMD and no variant) have decreased iC3b generation compared to controls. Type 3 variants portray normal iC3b generation (P = 0.99, compared with no AMD and no variant; with P = 0.04, compared with AMD and no variant). Noncarriers (with and without AMD) also demonstrate normal iC3b generation.