Table 4A.
General linear model for infant brain volumetric measures and maternal prenatal distress scores in each trimester.
|
STEP 1 | ||||||
|---|---|---|---|---|---|---|
| Volumetric measures | Adj R2 | β | p | Partial η2 | CI | |
| LEFT AMYGDALA / ICV | ||||||
| MODEL A | EPDS 1 + SCL 1 | −0.019 | −1.3E-6 | 0.586 | 0.002 | −6.0 E-6–3.4E-6 |
| EPDS 2 + SCL 2 | −0.009 | −3.0E-7 | 0.223 | 0.012 | −7.9E-6–1.9E-6 | |
| EPDS 3 + SCL 3 | −0.015 | −2.1E-6 | 0.401 | 0.006 | −7.0E-6–2.8E-6 | |
| MODEL B | sex * EPDS 1 + SCL1 | −0.016 | 5.5E-6 | 0.252 | 0.011 | −3.9E-6–1.5E-5 |
| sex * EPDS 2 + SCL 2 | 0.018 | 10.0E-6 | 0.042* | 0.034 | 3.5E-7 – 2.0E-5 | |
| sex * EPDS 3 + SCL 3 | −0.004 | 7.7E-6 | 0.126 | 0.020 | −2.2E-6 – 1.7E-5 | |
| RIGHT AMYGDALA / ICV | ||||||
| MODEL A | EPDS 1 + SCL 1 | 0.019 | 1.8E-6 | 0.461 | 0.005 | −3.0E-6 – 6.6E-6 |
| EPDS 2 + SCL 2 | 0.016 | 1.2E-6 | 0.623 | 0.002 | −3.8E-6 – 6.3E-6 | |
| EPDS 3 + SCL 3 | 0.015 | 3.1E-7 | 0.905 | < 0.001 | −4.8E-6 – 5.4E-6 | |
| MODEL B | sex * EPDS 1 + SCL1 | 0.024 | 6.2E-6 | 0.203 | 0.014 | −3.4E-6 – 1.6E-6 |
| sex * EPDS 2 + SCL 2 | 0.048 | 1.1E-5 | 0.029* | 0.040 | 1.2E-6–2.1E-5 | |
| sex * EPDS 3 + SCL 3 | 0.035 | 9.6E-6 | 0.061 | 0.029 | −4.6E-7–1.0E-5 | |
| LEFT HIPPOCAMPUS / ICV | ||||||
| MODEL A | EPDS 1 + SCL 1 | −0.007 | −5.1E-6 | 0.478 | 0.004 | −1.9E-5–9.2E-6 |
| EPDS 2 + SCL 2 | −0.011 | 6.2E-7 | 0.934 | <0.001 | −1.4E-5–1.6E-5 | |
| EPDS 3 + SCL 3 | −0.002 | 8.0E-6 | 0.291 | 0.009 | −6.9E-6–2.3E-5 | |
| MODEL B | sex * EPDS 1 + SCL1 | −0.013 | −8.0E-6 | 0.548 | 0.003 | −3.7E-5–2.1E-5 |
| sex * EPDS 2 + SCL 2 | −0.017 | −9.4E-6 | 0.536 | 0.003 | −3.9E-5–2.1E-5 | |
| sex * EPDS 3 + SCL 3 | −0.002 | −1.6E-5 | 0.306 | 0.009 | −4.6E-5–1.4E-5 | |
| RIGHT HIPPOCAMPUS / ICV | ||||||
| MODEL A | EPDS 1 + SCL 1 | −0.013 | 2.1E-6 | 0.757 | 0.001 | −1.1E-5–1.5E-5 |
| EPDS 2 + SCL 2 | −0.012 | 3.9E-6 | 0.577 | 0.003 | −9.8E-6–1.8E-5 | |
| EPDS 3 + SCL 3 | −0.010 | 4.6E-6 | 0.506 | 0.004 | −9.1E-6–1.8E-5 | |
| MODEL B | sex * EPDS 1 + SCL1 | −0.018 | −9.1E-6 | 0.496 | 0.004 | −3.6E-5–1.7E-5 |
| sex * EPDS 2 + SCL 2 | −0.020 | −2.1E-6 | 0.881 | <0.001 | −3.0E-5–2.5E-5 | |
| sex * EPDS 3 + SCL 3 | −0.019 | −2.8E-6 | 0.840 | <0.001 | −3.1E-5–2.5E-5 | |
Models A and B were tested separately in each pregnancy time point. *Significant uncorrected results (p < 0.05); Step 1) adjusted for infant sex, infant age at scan counted from due date; ICV = intracranial volume; SCL, Symptom Checklist −90; EPDS, Edinburgh Postnatal Depression Scale.