Table 2.
Association between selected baseline characteristics and incident anogenital HPV infection in women aged 24 to 45 years.
| Baseline characteristics | Age-adjusted hazard ratio (95% CI) for incident HPV DNA infection |
||
|---|---|---|---|
| HPV 16/18 | HPV 31/33/45/52/58, not 16/18 | HPV 16/18/31/33/45/52/58 | |
| Age, years | |||
| 24–29 (n = 250) | 1.00 | 1.00 | 1.00 |
| 30–34 (n = 223) | 0.93 (0.53–1.63) | 0.72 (0.41–1.24) | 0.83 (0.55–1.26) |
| 35–39 (n = 231) | 0.39 (0.19–0.81) | 0.64 (0.37–1.11) | 0.58 (0.37–0.91) |
| 40–45 (n = 285) | 0.56 (0.30–1.02) | 0.52 (0.30–0.91) | 0.55 (0.36–0.85) |
| Marital status | |||
| Married, first marriage (n = 512) | 1.00 | 1.00 | 1.00 |
| All others (n = 477) | 1.80 (1.12–2.91) | 1.43 (0.94–2.18) | 1.48 (1.07–2.05) |
| Regiona | |||
| North America (n = 101) | 1.00 | 1.00 | 1.00 |
| Europe (n = 119) | 1.17 (0.42–3.29) | 0.46 (0.19–1.12) | 0.60 (0.30–1.18) |
| Latin America (n = 387) | 2.39 (1.02–5.60) | 1.18 (0.64–2.16) | 1.43 (0.87–2.34) |
| Asia (n = 382) | 0.61 (0.23, 1.62) | 0.36 (0.18, 0.74) | 0.42 (0.23–0.74) |
| Race/Ethnicity | |||
| White (n = 189) | 1.00 | 1.00 | 1.00 |
| Black (n = 16) | N/A (N/A) | 3.23 (1.08–9.67) | 1.80 (0.63–5.13) |
| Hispanic (n = 398) | 1.93 (1.06–3.52) | 1.86 (1.06–3.25) | 1.87 (1.22–2.86) |
| Asia/Pacific (n = 386) | 0.54 (0.26–1.14) | 0.62 (0.32–1.20) | 0.60 (0.36–0.99) |
| Smoking status | |||
| Current (n = 129) | 1.00 | 1.00 | 1.00 |
| Former (n = 63) | 0.69 (0.22–2.11) | 0.20 (0.05–0.84) | 0.33 (0.13–0.85) |
| Never (n = 797) | 0.74 (0.40–1.34) | 0.53 (0.33–0.87) | 0.61 (0.41–0.90) |
| Age at first intercourse, years | |||
| ≤17 (n = 332) | 1.00 | 1.00 | 1.00 |
| 18-19 (n = 251) | 0.98 (0.58–1.66) | 0.86 (0.53–1.37) | 0.88 (0.61–1.28) |
| 20-22 (n = 206) | 0.68 (0.36–1.26) | 0.54 (0.30–0.98) | 0.63 (0.41–0.98) |
| ≥23 (n = 199) | 0.21 (0.08–0.61) | 0.27 (0.12–0.61) | 0.26 (0.14–0.49) |
| Lifetime number of sex partners | |||
| 1 (n = 515) | 1.00 | 1.00 | 1.00 |
| 2–3 (n = 286) | 1.58 (0.93–2.69) | 2.23 (1.34–3.71) | 1.85 (1.27–2.71) |
| ≥4 (n = 186) | 1.90 (1.08–3.34) | 3.52 (2.12–5.85) | 2.66 (1.80–3.92) |
| Number of new sex partners in last 6 months | |||
| 0 (n = 936) | 1.00 | 1.00 | 1.00 |
| 1 (n = 47) | 1.73 (0.79–3.79) | 1.96 (0.98–3.94) | 2.05 (1.20–3.51) |
| 2–3 (n = 2) | 6.37 (0.88–46.29) | 6.22 (0.85–45.23) | 3.47 (0.48–25.02) |
| ≥4 (n = 1) | N/A (N/A) | N/A (N/A) | N/A (N/A) |
| Number of prior pregnancies | |||
| 0 (n = 162) | 1.00 | 1.00 | 1.00 |
| 1–2 (n = 441) | 0.83 (0.45–1.52) | 1.49 (0.80–2.78) | 1.10 (0.70–1.73) |
| 3–4 (n = 300) | 0.83 (0.41–1.68) | 1.71 (0.87–3.38) | 1.22 (0.74–2.02) |
| 5+ (n = 86) | 0.96 (0.36–2.55) | 1.02 (0.35–2.94) | 0.95 (0.45–2.01) |
| Chlamydia/gonorrhea positive | |||
| No (n = 956) | 1.00 | 1.00 | 1.00 |
| Yes (n = 33) | 2.09 (0.84–5.18) | 2.95 (1.43–6.10) | 2.19 (1.15–4.16) |
“CI”: confidence interval; “HPV”: human papillomavirus; “N/A”: not applicable.
a
North America includes United States; Europe includes France, Germany, and Spain; Latin America includes Colombia; and Asia includes Philippines and Thailand.