Table 1.
Subject demographics.
| Variable | Controls (n = 225) |
MCI (n = 315) |
AD (n = 121) |
AD vs MCI |
F Controls vs MCI |
Controls vs AD | P |
|---|---|---|---|---|---|---|---|
| Age (mean, SD) | 75.58 ± 6.65 | 73.21 ± 7.93 | 75.77 ± 7.38 | 1.15 | 0.70 | 0.80 | 0.0002*,† |
| Sex (M/F) | 127/98 | 203/112 | 82/39 | 1.04 | 1.07 | 1.12 | 0.15 |
| MMSE at baseline (mean, SD) | 29.14 ± 1.11 | 27.95 ± 1.86 | 21.39 ± 4.62 | 0.17 | 0.34 | 0.06 | p < .0001*,†,‡ |
| NPI Total Score at baseline (mean, SD) | 1.17 ± 2.45 | 5.34 ± 7.99 | 8.51 ± 9.32 | 0.76 | 0.09 | 0.76 | p < .001*,†,‡ |
| Hyperactivity subsyndrome score | 1.20 ± 1.87 | 2.87 ± 3.28 | 4.40 ± 4.11 | 0.64 | 0.32 | 0.21 | p < .001*,†,‡ |
| Psychosis subsyndrome score | 0.85 ± 1.54 | 1.45 ± 1.94 | 2.15 ± 2.97 | 0.43 | 0.63 | 0.27 | p < .001*,†,‡ |
| Affective subsyndrome score | 1.57 ± 2.37 | 3.26 ± 3.36 | 3.85 ± 3.22 | 1.09 | 0.50 | 0.54 | p < .001†,‡ |
| Apathy subsyndrome score | 0.76 ± 1.25 | 2.16 ± 3.11 | 3.30 ± 3.39 | 0.84 | 0.16 | 0.14 | p < .001†,‡ |
| Number of visits | |||||||
| 1 | 24 | 39 | 25 | ||||
| 2 | 43 | 51 | 45 | ||||
| 3 | 47 | 50 | 23 | ||||
| 4 | 84 | 66 | 14 | ||||
| 5 | 25 | 93 | 13 | ||||
| 6 | 2 | 16 | 1 |
MCI = Mild cognitive impairment; AD = Alzheimer’s disease; MMSE = Mini-Mental State Examination; NPI = Neuropsychiatric Inventory.
*
p < .01 between AD and MCI.
‡
p < .01 between Controls and AD.
†
p < .01 between Controls and MCI.