Table 4.

Summary of the linear mixed-effects models examining factors contributing to NPS subsyndromes including WMH load as a predictor in the model. Regression coefficients, confidence intervals and p-values are shown for each predictor and NPS subsyndrome. Statistically significant values are indicated in bold.

Variable	Hyperactivity			Psychosis			Affective			Apathy
	β	95% CI	p	β	95% CI	p	β	95% CI	p	β	95% CI	p
Intercept	−0.34	−0.60 to −0.10	0.006	−0.12	−0.40 to 0.15	0.45	−0.25	−0.52 to 0.0003	0.05	−0.31	−0.59 to −0.02	0.03
WMH load	0.12	0.06–0.18	<0.001	0.11	0.05–0.18	<0.001	0.11	0.05–0.16	<0.001	0.12	0.06–0.18	<0.001
Age	−0.08	−0.15 to −0.01	0.02	−0.09	−0.16 to −0.02	0.006	−0.07	−0.14 to −0.006	0.07	−0.04	−0.11 to 0.03	0.28
AD	0.92	0.75–1.09	<0.001	0.65	0.48–0.83	<0.001	0.73	0.57–0.90	<0.001	0.93	0.76–1.10	<0.001
MCI	0.42	0.29–0.56	<0.001	0.22	0.09–0.36	0.001	0.41	0.28–0.54	<0.001	0.38	0.25–0.51	<0.001
Sex (male)	0.08	−0.06 to 0.21	0.26	−0.05	−0.18 to 0.09	0.49	−0.02	−0.16 to 0.12	0.78	0.10	−0.03 to 0.22	0.14

NPS = neuropsychiatric symptom; WMH = white matter hyperintensity; MCI = mild cognitive impairment; AD = Alzheimer’s disease.