Table 1.
Clinical Characteristics of Patients With Asymptomatic and Symptomatic Castleman Disease
| Asymptomatic UCD (n = 29) | Symptomatic | ||
|---|---|---|---|
| UCD (n = 8) | MCD (n = 2) | ||
| Sex, male:female | 11:18 | 2:6 | 2:0 |
| Age, y, median (range) | 11 (2-18) | 11.5 (6-22) | 13.5 (13-14) |
| Location of primary disease, n (%) | |||
| Neck/parotid | 20 (69) | 0 (0) | 1 (50) |
| Axilla | 3 (10) | 0 (0) | 1 (50) |
| Chest wall | 2 (7) | 0 (0) | 0 (0) |
| Mediastinum | 3 (10) | 1 (13) | 1 (50) |
| Small bowel mesentery | 0 (0) | 3 (38) | 0 (0) |
| Periportal | 0 (0) | 1 (13) | 0 (0) |
| Retroperitoneum | 1 (3) | 3 (38) | 0 (0) |
| Diffuse lymphadenopathy | 0 (0) | 0 (0) | 1 (50) |
| Length of signs/symptoms to diagnosis, mo, median (range) | 5.0 (0.13-36) | 25.5 (2-72)a | 7.5 (1-14) |
| Largest dimension of single lesion, cm, median (range) | 4.0 (2.2-7) | 5.0 (4.1-11)a | 8.15 (1.8-14.5)a |
| Complete surgical excision on first surgery, No. (%) | 23 (79) | 4/7 (57) | 0 (0) |
| Complete reexcision performed, No. (%) | 3/6 (50) | 1/3 (33) | 1/2 (50) |
| Clinical follow-up documented, No. (%) | 16 (55) | 6 (75) | 2 (100) |
| Length of follow-up, mo, median (range) | 5.5 (0.75-102) | 16 (8-84) | 12.5 (7-18) |
MCD, multicentric disease; UCD, unicentric disease; .
aSignificantly increased compared with asymptomatic patients.