Table 2.
Symptoms and Laboratory Values of Patients With Asymptomatic and Symptomatic Castleman Disease
| Asymptomatic UCD (n = 29) | Symptomatic | ||
|---|---|---|---|
| UCD (n = 8) | MCD (n = 2) | ||
| Symptoms | |||
| Fever | 0/29 (0) | 3/8 (38)a | 2/2 (100)a |
| Fatigue | 0/29 (0) | 2/8 (25)a | 2/2 (100)a |
| Failure to thrive/weight loss | 0/29 (0) | 3/8 (38)a | 1/2 (50) |
| Nausea/vomiting/abdominal pain | 0/29 (0) | 3/8 (38)a | 1/2 (50) |
| Gastrointestinal bleeding | 0/29 (0) | 1/8 (13) | 0/2 (0) |
| Joint pain and swelling | 0/29 (0) | 1/8 (13) | 0/2 (0) |
| Shortness of breath and/or cough | 0/29 (0) | 1/8 (13) | 0/2 (0) |
| Congestion | 0/29 (0) | 0/8 (0) | 1/2 (50) |
| Headache | 0/29 (0) | 0/8 (0) | 1/2 (50) |
| Night sweats | 0/29 (0) | 0/8 (0) | 2/2 (100)a |
| Splenomegaly | 0/29 (0) | 1/8 (13) | 1/2 (50) |
| Ascites | 0/29 (0) | 0/8 (0) | 1/2 (50) |
| Pleural effusion | 0/29 (0) | 0/8 (0) | 1/2 (50) |
| Pericardial effusion | 0/29 (0) | 1/8 (13) | 0/2 (0) |
| Renal failure | 0/29 (0) | 0/8 (0) | 1/2 (50) |
| Bone marrow myelofibrosis | 0/29 (0) | 0/8 (0) | 1/2 (50) |
| Paraneoplastic pemphigus | 0/29 (0) | 1/8 (13) | 0/2 (0) |
| Abnormal laboratory values | |||
| Decreased hemoglobin, No./total No. (%) | 0/15 (0) | 7/7 (100)a | 2/2 (100)a |
| Hemoglobin, g/dL, median (range) | 13.4 (10.8-14.5) | 8.4 (5.2-10.6)a | 8.7 (8.3-9.0)a |
| Decreased MCV, No./total No. (%) | 0/15 (0) | 5/6 (83)a | 1/2 (50) |
| MCV, fL, median (range) | 84.3 (78.1-94.0) | 64 (56.1-76.6)a | 75 (67-83)a |
| Leukocytosis, No./total No. (%) | 1/15 (7) | 0/6 (0) | 1/2 (50) |
| Leukopenia, No./total No. (%) | 0/15 (0) | 1/6 (17) | 0/2 (0) |
| WBC, x 103/μL, median (range) | 7.63 (4.5-10.99) | 6.79 (3.23-8.45) | 11.3 (9.8-12.7)a |
| Thrombocytosis, No./total No. (%) | 2/15 (13) | 4/7 (57) | 1/2 (50) |
| Thrombocytopenia, No./total No. (%) | 0/15 (0) | 1/7 (14) | 1/2 (50) |
| Platelets, x 103/μL, median (range) | 268.5 (204-574) | 485 (75-746) | 352 (83-621) |
| Elevated ESR | 4/8 (50) | 6/6 (100) | 2/2 (100) |
| ESR, mm/h, median (range) | 16.5 (1-37) | 96 (28 to >140)a | 116 (100-132)a |
| Elevated CRP, No./total No. (%) | 3/6 (50) | 5/6 (83) | 2/2 (100) |
| CRP, mg/dL, median (range) | 1.0 (0.1-4.8) | 11.37 (0.06-17.15)a | 25.6 (24.1-27)a |
| Hypoalbuminemia, No./total No. (%) | 0/5 (0) | 4/6 (67) | 2/2 (100) |
| Albumin, g/dL, median (range) | 4.4 (4.1-4.6) | 3.3 (2.0-4.1)a | 3.0 (2.7-3.2)a |
| Elevated IgG, No./total No. (%) | 0/5 (0) | 2/6 (33)b | 1/2 (50) |
| IgG, mg/dL, median (range) | 991 (892-1431) | 1,004 (655-13,744) | 2,605 (1,180-4,030) |
| Elevated IL-6, No./total No. (%) | 1/2 (50) | 1/2 (50) | 0/1 (0) |
| IL-6, pg/mL, median (range) | <10 (<5 to 15) | 41 (5-77) | <10 (<10) |
CRP, c-reactive protein; ESR, erythrocyte sedimentation rate; MCD, multicentric disease; MCV, mean corpuscular volume; UCD, unicentric disease.
aSignificantly different compared with asymptomatic patients.
bTwo values determined >1 mo after excisional biopsy, and both remained elevated.