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Effect of EA11 on the AKT and MAPK signaling pathways. p-ERK, ERK, p-JNK, JNK, p-p38, p38, p-AKT, and AKT protein expressions were assessed by western blot following treatment with 25 or 50 μg/ml of EA11. Band intensity was determined using an imaging system. Band expression levels were calculated relative to the intensity of total JNK/ERK/p38/AKT protein. ∗P < 0.05, ∗∗P < 0.01 vs. C group.
