Fig. 3.

Age-dependent changes in OPC morphology in the CA1 hippocampus of 3xTg-AD and age-matched non-Tg controls. (A–D) Representative confocal images of NG2 immunopositive OPCs in the CA1 region of the hippocampus, illustrating in magenta the outline used for analysis of individual cells using the Cell Analyst program (Chvátal et al., 2007); scale bars = 10 μm. (E–H) Quantification of OPC total cell volume (E), cell body surface area (F), cell body volume (G) and total cell surface area (H); data are mean ± SEM from 25 cells from 3 sections per mouse, where n = 3 or 4). ∗p < 0.05, ∗∗p < 0.01, ∗∗∗∗p < 0.0001 unpaired t-tests.