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. 2020 Oct;94:130–139. doi: 10.1016/j.neurobiolaging.2020.05.016

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© 2020 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 4 — Relationships between OPCs and Aβ plaques in the hippocampus of 24-month 3xTg-AD. Confocal images of coronal brain sections from 24-month 3xTg-AD double immunostained for NG2 (green) and Aβ (red). (A) Overview of the association of OPCs with Aβ in the CA1 area of the hippocampus, with merged image (Ai) and indvidual channels for NG2 (Aii) and Aβ (Aiii). (B) OPCs clustering around Aβ plaque in maximum intensity z-stack projection (Bi) and single z-section (Bii). (C) Maximum intensity z-stack projection of OPC within the boundary of multiple Aβ plaques. (D) OPC embedded within an Aβ plaque in maximum intensity z-stack projection (Di) and orthogonal section (Dii). Scale bars = 50 μm in A, 25 μm in B and 20 μm in C, D. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)