Table II.

Centralities analysis of the top 20 hub genes identified in the protein-protein interaction network from differentially expressed genes in acute ischemic stress.

Gene	Degree centrality	Gene	Betweenness centrality	Gene	Closeness centrality
STAT3	96	HDAC1	0.066077	STAT3	0.39361
RHOA	89	BCL2	0.065222	MAPK14	0.384987
FYN	85	STAT3	0.062793	BCL2	0.383381
MAPK14	80	RHOA	0.056532	CREBBP	0.38289
CREBBP	79	ACTB	0.050714	FOS	0.381667
BCL2	72	CREBBP	0.049029	RHOA	0.380331
CDC42	71	CDC42	0.047746	MAPK1	0.377329
HDAC1	71	MAPK14	0.041837	STAT1	0.376734
STAT1	71	FYN	0.040107	MAPK3	0.375196
MAPK1	71	STAT1	0.036472	FYN	0.369855
FOS	71	NOTCH1	0.035509	NOTCH1	0.36724
MAPK3	66	FOS	0.034142	ACTB	0.366564
GRB2	61	HIF1A	0.033411	HDAC1	0.363443
ACTB	58	GRB2	0.030588	PTEN	0.363332
NOTCH1	53	MAPK1	0.029564	CDC42	0.362891
TLR4	49	GSK3B	0.023502	GSK3B	0.362891
PXN	49	PTEN	0.023476	PXN	0.362121
GSK3B	47	MAPK3	0.020408	TLR4	0.360265
HIF1A	47	TLR4	0.019773	GRB2	0.360048
PTEN	47	PXN	0.013521	HIF1A	0.35929

STAT3, signal transducer and activator of transcription 3; RHOA, Ras homolog family member A; FYN, FYN Proto-oncogene tyrosine-protein kinase; MAPK14, mitogen-activated protein kinase 14; CREBBP, CREB binding protein; BCL2, BCL2 apoptosis regulator; CDC42, cell division cycle 42; HDAC1, histone deacetylase 1; STAT1, signal transducer and activator of transcription 1; MAPK1, mitogen-activated protein kinase 1; FOS, Fos proto-oncogene AP-1 transcription factor subunit; MAPK3, mitogen-activated protein kinase 3; GRB2, growth factor receptor bound protein 2; ACTB, actin β; NOTCH1, notch receptor 1; TLR4, toll-like receptor 4; PXN, paxillin; GSK3B, glycogen synthase kinase 3 β; HIF1A, hypoxia inducible factor 1 subunit α; PTEN, phosphatase and tensin homolog.