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. 2020 Aug 27;27:90. doi: 10.1186/s12929-020-00683-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — STRING analysis a) STRING analysis: CN: network representing the interaction among the examined cytokines (Cytokines Network, CN), as reported in STRING tool. The data are filtered for Homo sapiens and with a medium confidence score (0.400). The nodes and links are represented with the default layout and using the edge-weighted spring embedded layout (weighted for edge betweenness). The most relevant nodes as defined by PCA analysis are edged in red. b) STRING analysis: previous network after 4 cycles of enrichment (Enriched Cytokines Network, ECN). The nodes and links are represented with the default layout and using the edge-weighted spring embedded layout (weighted for edge betweenness). The most relevant nodes as defined by PCA analysis are edged in red