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. 2020 Jul 23;22(4):2957–2965. doi: 10.3892/mmr.2020.11354

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Mannose increases the cisplatin-mediated apoptosis of NSCLC cells in vitro. (A) CCK-8 cell viability assays were conducted to determine the IC₅₀ of cisplatin against A549 and H1299 cells at 24 h. (B) Flow cytometry was performed to evaluate the effects of mannose, cisplatin, or a combination of cisplatin and mannose on the apoptosis of NSCLC cells in vitro. Early apoptotic cells are represented in the bottom right field (Annexin V+/PI-). Late apoptotic cells are represented in the top right field (Annexin V+/PI+). (C and D) Western blotting was conducted to evaluate the effects of mannose, cisplatin, or a combination of cisplatin and mannose on the expression of apoptosis-related proteins, including cleaved caspase-3, Bax and Bcl-2. Data are presented as the mean ± standard deviation. *P<0.05, **P<0.01, ***P<0.001. NSCLC, non-small cell lung cancer; ctrl, control; PI, propidium iodide.