Table II.
Univariate and multivariate analysis of clinical characteristics of overall survival using Cox regression model.
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Characteristics | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Age | 1.51 (0.88-2.60) | 0.212 | 1.34 (0.70-2.25) | 0.375 |
| Family history | 1.34 (0.51-3.44) | 0.513 | ||
| Tumor grade | 1.89 (1.03-3.44) | 0.032 | 1.70 (0.93-3.11) | 0.082 |
| TNM stage | 2.42 (1.41-4.20) | 0.004 | 2.31 (1.34-4.02) | 0.006 |
| Lymph node metastasis | 1.98 (1.11-3.62) | 0.017 | 1.23 (0.37-3.86) | 0.672 |
| ER status | 0.74 (0.36-1.19) | 0.323 | ||
| PR status | 0.77 (0.38-1.21) | 0.513 | ||
| HER2 status | 0.81 (0.42-1.39) | 0.472 | ||
| HEIH expression | 5.19 (3.21-9.84) | <0.001 | 4.97 (3.19-9.66) | <0.001 |
HR, hazard ratio; CI, confidence interval; TNM, tumor-node-metastasis; ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor-2; HEIH, high expression in hepatocellular carcinoma.