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. 2020 Aug 19;22(4):3049–3056. doi: 10.3892/mmr.2020.11435

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Copyright: © Zhou et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — GAS5 regulates gene expression, and the relationship between GAS5 and p53 network. (A) Regulation of gene expression by lncRNA GAS5. GAS5 regulates the expression level of genes and enhances the interaction of E2F1 and P27kip1 by activating E2F1. GAS5 binds to eIF4E to inhibit c-Myc mRNA expression. GAS5 indirectly enhances the expression of PTEN by directly inhibiting the expression of miR-21a-5p. (B) GAS5 and the p53 network. Feedback adjustment of lncRNA GAS5 and p53. Following DNA damage, GAS5 can derive snoRNA, which directly promotes the expression of p53 and inhibits the G1 phase in the interphase of cell division. Solid edges represent direct regulatory effects. Dotted edges represent indirect regulatory effects. lncRNA, long noncoding RNA; GAS5, growth arrest-specific 5; E2F1, E2F transcription factor 1; P27kip1; cyclin-dependent kinase inhibitor 1B; eIF4E, eukaryotic translation initiation factor 4E; PTEN, phosphatase and tensin homologue deleted on chromosome 10; miR, microRNA; snoRNA, small nucleolar RNA.