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. 2020 Aug 19;22(4):3049–3056. doi: 10.3892/mmr.2020.11435

Figure 3.

Figure 3.

Relationship between GAS5 and miRNA, and the relationship between GAS5 and GRE. (A) The interaction of lncRNA GAS5 with miRNA. GAS5 activates PTEN, PDCD4 and miR-21 conjugates through competitive binding with miR-21. Additionally, GAS5 can directly bind to miR-103 to upregulate PTEN expression. (B) The association between lncRNA GAS5 and GRE. GAS5 competitively binds the DBD on the GR, preventing the binding of GR and GRE. Furthermore, GAS5 indirectly inhibits the expression of GR target genes cIAP2 and SGK1. Solid edges represent direct regulatory effects. Dotted edges represent indirect regulatory effects. lncRNA, long noncoding RNA; GAS5, growth arrest-specific 5; miRNA, microRNA; PTEN, phosphatase and tensin homologue deleted on chromosome 10; PDCD4, programmed cell death 4; GRE, glucocorticoid response element; DBD, DNA-binding domain; GR, glucocorticoid receptor; cIAP2, baculoviral IAP repeat-containing protein 3; SGK1, serum/glucocorticoid regulated kinase 1.