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. 2020 Aug 4;22(4):3440–3452. doi: 10.3892/mmr.2020.11407

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Copyright: © Pang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Resveratrol activates autophagy through the miR-4654/Rheb axis. (A) Cell viability was analyzed in HSFBs in the different groups using an MTT assay. *P<0.05, **P<0.01, ***P<0.001. (B) RT-qPCR analysis of the expression levels of Rheb in HSFBs in the different groups. **P<0.01, ***P<0.001; ^##P<0.01 vs. the resveratrol group. (C) Western blotting was used to analyze the protein expression levels of Rheb, LC3 and Beclin 1 in HSFBs in the different groups. *P<0.05, **P<0.01, ***P<0.001; ^#P<0.05, ^##P<0.01 vs. the resveratrol group. Data are presented as the mean ± SD. N=3. HSFBs, hypertrophic scar-derived fibroblasts; LC3, microtubule-associated protein 1A/1B-light chain 3; Control, mimic-NC + inhibitor-NC + PBS + vector group; OE, overexpression; KD, knockdown; miR, microRNA.