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. 2020 Aug 5;22(4):3418–3428. doi: 10.3892/mmr.2020.11420

Figure 1.

Figure 1.

GI regulates the physiology and pathology of UC mice. The mice were continuously exposed to DSS (3.5% DSS dissolved in D.D. water) for 28 days, SASP (0.6 g/kg of SASP dissolved in D.D. water) and GI (1.0, 2.0 and 4.0 g/kg of GI suspended in D.D. water) were administered from the 7th day. (A) GI reduced the DAI index of UC mice and (B) ameliorated the shortening of colon length. Hematoxylin and eosin staining of (C) colon (scale bar, 100 µm; magnification, ×40), (D) colon, (E) spleen, (F) liver and (G) kidney tissues (scale bar, 100 µm; magnification, ×400) from C57BL/6 mice. ###P<0.001 vs. control mice; *P<0.05, **P<0.01 and ***P<0.001 vs. DSS-induced UC mice. GI, Gloeostereum incarnatum; UC, ulcerative colitis; DSS, dextran sulfate sodium; D.D., double distilled; SASP, sulfasalazine; DAI, disease activity index.