Table III.
3.5% dextran sulfate sodium | ||||||
---|---|---|---|---|---|---|
GI, g/kg | ||||||
Inflammatory factors | Control | Model | SASP, 0.6 g/kg | 1.0 | 2.0 | 4.0 |
IL-1β, pg/mgprot | 45.7±3.9 | 60.0±3.5a | 44.1±3.1d | 48.4±1.4c | 42.2±3.8c | 39.7±3.7d |
IL-2, pg/mgprot | 158.1±9.4 | 219.1±14.6a | 153.8±11.9c | 130.2±11.0d | 149.5±16.4c | 128.4±10.1d |
IL-6, pg/mgprot | 61.6±3.7 | 83.7±6.3a | 54.5±8.2c | 57.3±1.4c | 62.1±6.8 | 50.0±4.8d |
IL-12, pg/mgprot | 37.3±2.6 | 57.2±6.3a | 31.9±3.9d | 30.5±2.0d | 39.6±2.0c | 27.8±2.1d |
TNF-α, pg/mgprot | 407.5±21.9 | 489±22.2a | 429.0±28.9 | 374.5±27.2c | 358.0±43.1c | 337.5±14.6d |
TNF-β, pg/mgprot | 78.6±7.8 | 119.8±11.5b | 62.9±7.7d | 70.1±4.1d | 83.6±10.9c | 63.3±4.4d |
IFN-α, pg/mgprot | 19.7±1.6 | 28.8±2.6b | 16.3±1.9d | 20.7±1.2c | 20.2±1.6c | 17.2±1.8d |
IFN-γ, pg/mgprot | 72.4±6.6 | 126.6±14.8b | 72.9±9.5d | 75.3±5.4d | 84.2±5.5c | 69.8±7.0c |
Data were analyzed using a one-way ANOVA and are expressed as mean ± SEM (n=8).
P<0.05
P<0.01 vs. control mice
P<0.05
P<0.01 vs. DSS-induced UC mice. GI, Gloeostereum incarnatum; IL, interleukin; TNF, tumor necrosis factor; IFN, interferon.