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. Author manuscript; available in PMC: 2020 Aug 28.
Published in final edited form as: Epilepsia. 2020 Apr 3;61(5):856–867. doi: 10.1111/epi.16490

Figure 3.

Figure 3

Glutamic acid decarboxylase 2 (Gad2) neurons at ictal onset sites. A Nissl-stained section with a box denoting a 250 μm radius centered on the electrode tip with the highest z-score for recording earliest seizure activity. m = molecular layer, g = granule cell layer, h = hilus, S = subiculum. B Gad2 neurons in the dentate gyrus of a control rat. DAPI in blue. C Gad2 neurons at the ictal onset site centered on the electrode tip as demarcated in A but in a nearby section. D Gad2 in situ at the contralateral site. E Quantification of Gad2 neuron profiles at the ictal onset site and contralaterally for each rat. Averages indicated by horizontal black lines. Error bars are s.e.m. Magenta lines indicate rats in which the contralateral site was not a site of significantly earliest seizure activity.