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. Author manuscript; available in PMC: 2020 Aug 28.
Published in final edited form as: Curr Treat Options Gastroenterol. 2018 Dec;16(4):561–569. doi: 10.1007/s11938-018-0203-1

Table.

Changing patterns of gastric cancer epidemiology

graphic file with name nihms-1617430-t0001.jpg graphic file with name nihms-1617430-t0002.jpg graphic file with name nihms-1617430-t0003.jpg
Classic Modern Future
Phenotype Anatomical predilection Antrum Cardia Corpus
Histology Intestinal Both Diffuse
Population Race/ethnicity Asians Caucasians Caucasians
Male predominance ++ +++ −
Risk factors Old age +++ ++ +
Low socioeconomic status +++ +/− −
H, pylori +++ +/− +/−
Peptic ulcer disease ++ − −
Obesity − ++ −
Autoimmunity − − ++?
Gastric Microecology Microbiome diversity − +? ++?
Gastric acidity +++ ++ +

Hatched circles indicate anatomical predilection of each phenotype (Modified from: Atherton and Blaser, 2009 [55]).