Table 1.
Top 10 up/down regulated mRNAs in cit-AgNP and PVP-AgNP exposed mice.
| Gene | Gene Description | Fold - Change | P value |
|---|---|---|---|
| Cit-AgNPs | |||
| Arrdc3 | arrestin domain containing 3 | −6.52 | 3.41E-04 |
| Serpina7 | serine (or cysteine) peptidase inhibitor, clade A, member 7 | −3.37 | 4.97E-02 |
| Id2 | inhibitor of DNA binding 2 | −3.05 | 1.26E-02 |
| Acaa1b | acetyl-Coenzyme A acyltransferase 1B | −2.9 | 3.62E-02 |
| Cyr61 | cysteine rich protein 61 | −2.87 | 3.44E-02 |
| Nr1d1 | nuclear receptor subfamily 1, group D, member 1 | −2.55 | 2.60E-02 |
| Gsta2 | glutathione S-transferase, alpha 2 (Yc2) | −2.45 | 3.55E-02 |
| Cited2 | Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 | −2.41 | 1.24E-03 |
| Fzd4 | frizzled homolog 4 | −2.35 | 1.76E-02 |
| Slc30a10 | solute carrier family 30, member 10 | −2.33 | 4.40E-02 |
| Arhgef26 | Rho guanine nucleotide exchange factor (GEF) 26 | 2.24 | 1.07E-03 |
| B3galt1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | 2.27 | 9.99E-03 |
| Grem2 | gremlin 2 homolog, cysteine knot superfamily | 2.29 | 1.58E-02 |
| Fam35a | family with sequence similarity 35, member A | 2.39 | 1.23E-02 |
| Pfkfb3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 2.5 | 1.42E-02 |
| Slc38a2 | solute carrier family 38, member 2 | 2.53 | 3.20E-02 |
| Nop58 | NOP58 ribonucleoprotein | 2.57 | 2.45E-02 |
| II1r1 | interleukin 1 receptor, type I | 2.83 | 4.02E-03 |
| Zbtb16 | zinc finger and BTB domain containing 16 | 5.32 | 1.71E-03 |
| Lpin1 | lipin 1 | 12.36 | 1.16E-03 |
| PVP-AgNPs | |||
| Cyp26a1 | cytochrome P450, family 26, subfamily a, polypeptide 1 | −4.03 | 4.22E-02 |
| Arrdc3 | arrestin domain containing 3 | −3.87 | 2.20E-02 |
| Txnip | thioredoxin interacting protein | −3.49 | 1.88E-03 |
| Krt23 | keratin 23 | −3.48 | 3.18E-02 |
| Slc17a4 | solute carrier family 17 (sodium phosphate), member 4 | −3.17 | 4.74E-02 |
| Pklr | pyruvate kinase liver and red blood cell | −3.16 | 3.36E-02 |
| Tubb2a | tubulin, beta 2A class IIA | −3.13 | 3.75E-03 |
| Gstm3 | glutathione S-transferase, mu 3 | −2.97 | 2.51E-02 |
| Gsta1 | glutathione S-transferase, alpha 1 (Ya) | −2.97 | 3.76E-02 |
| Tuba1c | tubulin, alpha 1C | −2.89 | 6.80E-03 |
| Ccdc152 | coiled-coil domain containing 152 | 1.93 | 1.49E-02 |
| C4b | complement component 4B (Chido blood group) | 2.01 | 1.86E-02 |
| Lurap1l | leucine rich adaptor protein 1-like | 2.02 | 1.99E-02 |
| Pros1 | protein S (alpha) | 2.08 | 2.87E-02 |
| Slc38a2 | solute carrier family 38, member 2 | 2.28 | 3.98E-02 |
| Sftpa1 | surfactant associated protein A1 | 2.32 | 7.58E-03 |
| Slc41a2 | solute carrier family 41, member 2 | 2.76 | 3.78E-02 |
| Fgl1 | fibrinogen-like protein 1 | 6.99 | 3.59E-02 |
| Saa1 | serum amyloid A1 | 45.94 | 1.29E-02 |
| Saa2 | serum amyloid A2 | 81.32 | 1.66E-02 |
mRNAs are arranged from top down to top up regulated. Commonly regulated mRNAs are highlighted in bold.